Neutrofilné extracelulárne pasce a ich vplyv v patogenéze vybraných ochorení

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    Autori: Ivana Thurzová, Vanesa Bajuszová, Jaromír Tupý

    In: Zdravotnícke štúdie

    ISSN: 1337-723X

    Ročník: 16

    Číslo: 1

    Strany: 39-44

    Rok vydania: 2024

    Vydavateľ: VERBUM – vydavateľstvo Katolíckej univerzity v Ružomberku

    Abstract: Neutrophil extracellular traps (NETs) are net-like extracellular structures extruded by activated neutrophils capable of trapping many pathogens, including Gram-positive and Gram-negative bacteria, fungi, protozoa, and viruses. NETs are composed of DNA strands, histones, and antimicrobial proteins derived from neutrophil granules and nuclei. Pathogens are immobilized in them and exposed to a local, high and lethal concentration of effector proteins. Excessive release of NETs or violation of their elimination mechanisms is associated with several disease states. Toxic products of NETs (histones, granule proteins) induce cell apoptosis, promote tissue damage and inflammation. Components of NETs can serve as autoantigens and initiate reactions important in the pathogenesis of several autoimmune diseases. The presence of an increased amount of circulating NETs can influence the progression of cancer disease, the formation of metastases and the failure of treatment. NETs also play an important role in coagulation and blood clot formation.

    Keywords: Neutrophil. Neutrophil extracellular traps. Autoimmunity. Tumor diseases. Coagulation.


    THURZOVÁ, Ivana – BAJUSZOVÁ, Vanesa – TUPÝ, Jaromír. Neutrofilné extracelulárne pasce a ich vplyv v patogenéze vybraných ochorení. In: Zdravotnícke štúdie [online]. Ružomberok: VERBUM – vydavateľstvo Katolíckej univerzity v Ružomberku, 2024, 16 (1), s. 39-44. ISSN 1337-723X. Dostupné na internete: