Rhabdomyolysis - A Syndrome of Striated Muscle Breakdown

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Autori/ Authors:  Karolína Jančoková       Lukáš Lacko      Lucián Zastko

In: Zdravotnícke štúdie

ISSN: 1337-723X

Ročník/ Volume: XVII

Číslo/ Issue: 2

Strany/ Page Range: 2-8

Rok vydania/ Publication Year: 2025

Jazyk/ Language: Slovak

Vydavateľ/ Publisher: VERBUM – vydavateľstvo Katolíckej univerzity v Ružomberku

Abstrakt/ Abstract: Rhabdomyolysis is a life-threatening syndrome characterized by the breakdown of striated muscle and the release of intracellular components into the bloodstream. Clinical manifestations are variable, ranging from an asymptomatic course with elevated creatine kinase to acute renal failure and disseminated intravascular coagulation. This work provides an overview of the definition, epidemiology, pathophysiology, and etiology of rhabdomyolysis. The pathophysiology is dominated by disruption of ionic homeostasis with uncontrolled calcium influx into muscle cells, leading to protease activation, mitochondrial dysfunction, oxidative stress and apoptosis. Histopathological examination of muscle biopsies may reveal necrosis of muscle fibers or specific findings in metabolic myopathies. Etiologically, rhabdomyolysis is divided into traumatic (crush syndrome, prolonged immobilization, ischemic muscle damage, thermal and electrical injury, exertional muscle damage) and nontraumatic causes (drugs, toxins, infections, electrolyte abnormalities, endocrine disorders, metabolic myopathies). Early diagnosis and adequate treatment aimed at hydration and elimination of triggering factors are crucial to minimize the risk of complications.

Kľúčové slová/ Keywords:  Rhabdomyolysis. Renal failure. Myoglobinuria. Creatine kinase. Striated muscles.

Citácia/ How to cite:

JANČOKOVÁ, Karolína; LACKO, Lukáš a ZASTKO, Lucián, 2025. Rabdomyolýza - syndróm rozpadu priečne pruhovaného svalstva. Zdravotnícke štúdie. Online. Roč. XVII, č. 2, s. 2-8. ISSN 1337-723X. Dostupné na:

Toto dielo je publikované pod/ This work is licensed under a Creative Commons Attribution 4.0 International License.